Delivery of a vector encoding BRAF(V600E) did not induce tumorigenesis, whereas 7 of 23 mice developed tumors when BRAF(V600E) was combined with KO of Cdkn2a. Notably, these tumors were much less aggressive than those of the aforementioned models, recapitulating the intermediate grade of pleomorphic xanthoastrocytoma that is typically driven by these two hits (Fig. 1q). Here, CDKN2A is linked to pleomorphic xanthoastrocytoma.