Analysis of differentially methylated CpG sites in promoter regions between tumor types highlighted tumor-driving oncogenes51 such as MYC in MB grade 3 but also revealed potential drivers that have only recently been brought into context with the respective entity, such as PDGFB for EPN ZFTA52 or PIK3R1 for IDH wild-type glioma53 (Fig. 2c). This evidence concerns the gene PIK3R1 and neoplasm.