Further, GPC6 and GPC4 release is reduced in the SOD1G93A model of ALS26, and work in Drosophila suggests Dlp is a target of TDP-43 proteinopathy, with reduced expression at the neuromuscular junction (NMJ)37. The gene discussed is GPC6; the disease is amyotrophic lateral sclerosis 26 with or without frontotemporal dementia.