In addition to studies of ASL regulation on non-CF airway cultures, we also assessed the effect of pharmacological rescue of CFTR by the combination of the corrector VX-809 (lumacaftor) and the potentiator VX-770 (ivacaftor) in nasal epithelial cultures from patients with CF homozygous for the F508del mutation. Here, CFTR is linked to cystic fibrosis.