Overexpression of the wild-type or a mutant form of amyloid precursor protein (APP), another protein aggregating in AD-affected brains, also causes Golgi fragmentation, possibly via the indirect effect of the APP-derived peptide Aβ on the phosphorylation of Golgi structural proteins such as GRASP65 (Joshi et al, 2014). Here, APP is linked to Alzheimer disease.