TF and metastatic neoplasm: Intriguingly, in selected patients with follow-up data available at multiple timepoints, we observed a paired fluctuation of TF and carcinoembryonic antigen (CEA), both in patients who did not experience a disease relapse and had low TF and clinically nonrelevant CEA values (patients 2, 5 and 19 in Supplementary Fig. 7) and in patients who later developed metastatic disease and had the highest CEA and TF (patients 11 and 29 in Supplementary Fig. 7).