The SAF values significantly differed between the groups with and without hypertension (p = 0.003), dyslipidemia (p = 0.035), macroangiopathy (p = 0.005), neuropathy (p = 0.008), diet therapy (p = 0.001), insulin use (p = 0.021), diuretic use (p = 0.024), and diabetic retinopathy stage (p = 0.013). The gene discussed is INS; the disease is hypertensive disorder.