Following interference with colorectal cells, the specific sequences targeting CaMKKβ demonstrated a significant inhibition of NaB-induced p-AMPKα and p-ACC protein expression, as depicted in Fig. 4C. More importantly, the results depicted in Fig. 4C demonstrate a significant reduction in the level of LC3II protein expression in colorectal cancer cells treated with NaB when CaMKKβ was down-regulated. Here, CAMKK2 is linked to colorectal cancer.