Consistent with previous studies, we detected the typical caloric restriction signature, with genes involved in metabolic signaling (Igfr, Irs1, FoxOs, Sirt1), circadian rhythms (Rora, Arntl, Clock, Cry1), lipid metabolism (Acot1, Angptl4, Hmgcr), and cancer (Myc, Cdkn1a, Brca2, Gadd45, Ctnnb1) being strongly regulated (Supplementary Fig. 1i). The gene discussed is CLOCK; the disease is cancer.