Consistent with previous studies, we detected the typical caloric restriction signature, with genes involved in metabolic signaling (Igfr, Irs1, FoxOs, Sirt1), circadian rhythms (Rora, Arntl, Clock, Cry1), lipid metabolism (Acot1, Angptl4, Hmgcr), and cancer (Myc, Cdkn1a, Brca2, Gadd45, Ctnnb1) being strongly regulated (Supplementary Fig. 1i). This evidence concerns the gene IRS1 and cancer.