LCN2 and colitis: In the colitis model, a correlation analysis between treatments (PBS or ARO112) and average disease activity index, colon shortening (using the inverse of the colon length at time of sacrifice—1/colon length), and fecal lipocalin-2 measured at the last day of DSS treatment, show that ARO112 treatment correlates negatively with all three disease markers, while PBS treatment associates positively with disease indicators (Supplementary Fig. 7b, two-tailed Kendall’s τ rank correlation, p < 0.05).