NOD2 and infection: Consistent with previous observations62, Nod2−/− mice were more susceptible to AIEC colonization in comparison with WT mice, with ~50% of the Nod2−/− mice still being colonized with AIEC after 20 days of infection (Fig. 4b, control animals), while all WT mice had cleared the infection in that same timeframe (Supplementary Fig. 3a, control mice).