Across all samples from all groups, we could discern three different levels of inflammation: high (>120 ng/ml), mild (>20 ng/ml), and low (<20 ng/ml) levels of fecal calprotectin, a marker for inflammation (Supplementary Fig. 5d, Kruskal-Wallis with Dunn’s correction for multiple comparisons, p < 0.0001), a much higher range than what we observed in our IBD model with Lcn2. This evidence concerns the gene LCN2 and inflammatory bowel disease.