Immunoblot (IB) analysis of AMO1 multiple myeloma (MM) cells, which express relatively high levels of IRE118, demonstrated that G6374 induced more potent and substantial depletion of the IRE1 protein as compared to CPD-2828, with a respective Dmax of 93 versus 71%, and a DC50 of 0.04 versus 0.64 μM (Fig. 1b). The gene discussed is ERN1; the disease is AL amyloidosis.