Specifically, we found that InN-derived NLGN2 and PTN signaling can influence ExNs by modulating the expression of key genes involved in neuronal migration, such as RUNX1, STMN1, TUBB, and TUBB2B. These molecules are integral to microtubule dynamics and neuronal movement, suggesting that the dysfunction of InNs in DS may lead to impaired ExN migration through disrupted regulation of cytoskeletal elements. Here, RUNX1 is linked to Dravet syndrome.