We chose ZFH-2 because of the large (> 20-fold) increase in ZFH-2 labeling by DAF-16::TbID at low IIS (Fig. 2c and Supplementary Data 1), and since its mammalian ortholog ZFHX3 is a tumor suppressor36, regulates nervous system development37, and has been associated with obesity38. The gene discussed is ZFHX2; the disease is neoplasm.