TP53 and Li-Fraumeni syndrome: Thus, the Trp53R210X/+ mice, like previously published Trp53-null and missense knock-in models, represent a valuable model for the Li-Fraumeni syndrome (LFS), in which TP53 nonsense mutations occur with a similar frequency as in somatic tumors according to The TP53 Database collection of germline variants (The TP53 Database (R21, Jan 2025): https://tp53.cancer.gov) [48].