DES and soft tissue sarcoma: The majority of soft-tissue sarcomas were myosarcomas – primarily leiomyosarcomas that were confirmed by positive desmin staining and negative myogenin staining, and rhabdomyosarcomas confirmed by positive desmin and negative myogenin staining (Figs. 3 and 4; Supplementary Fig. S2C, S3B, S5A; Supplementary Table S4A, B).