TP53 and neoplasm: One plausible explanation for this difference is that the truncated p53 protein encoded by the Trp53R210X allele exerts a less pronounced dominant-negative effect by oligomerization with co-expressed WT p53 as compared to R172H missense mutant p53, or completely lacks such effect, allowing more potent WT p53-dependent tumor suppression in Trp53R210X/+ mice.