The results of the rescue experiment demonstrated that FH overexpression abolished the effect of TRIM47 overexpression on ICC cells, including inhibiting cell viability (Fig. 8I), increasing caspase-3 activity (Fig. 8J), reducing fumarate level (Fig. 8K), and inhibiting M2 macrophage of TAMs (Fig. 8L). The gene discussed is FH; the disease is intrahepatic cholangiocarcinoma.