Both ATRX IFF neuroblastoma cell lines showed sensitivity to RA as a single agent (Fig 4A-D) and their clonogenicity was further reduced with the addition of either tazemetostat or the EZH2 degrader MS1943, at doses sufficient to reduce H3K27me3 levels (Fig 4A-E). The gene discussed is ATRX; the disease is neuroblastoma.