When combined with anti–programmed death-ligand 1 (anti–PD-L1) antibody (Ab) and laser radiation (690 nm, 200 mW/cm2, 10 min), HANP/VP significantly increased production of the pro-inflammatory cytokines interferon-γ (IFN-γ), IFN-β1, and tumor necrosis factor-α (TNF-α), enhanced dendritic-cell (DC) maturation and Cluster of Differentiation 8–positive (CD8+) T-cell expansion, suppressed tumor growth by 96.20 ± 7.22 %, and extended survival from 33 to >80 days in orthotopic UM models. Here, IFNB1 is linked to neoplasm.