This material alleviated hypoxia and boosted tumor immunity by inducing robust immunogenic cell death (ICD) via PDT, which promoted T-lymphocyte infiltration and converted tumors from “cold” to “hot.” In a subcutaneous-UM mouse model, TPA-BD combined with an anti–programmed death-ligand 1 (anti–PD-L1) antibody (Ab) markedly suppressed tumor growth [31]. Here, CD274 is linked to neoplasm.