The activation of NLRP3 mediates the downstream inflammatory response, and the overactivation of NLRP3 inflammatory is closely associated with the development of a variety of lung diseases for example the lung injury, pulmonary fibrosis, chronic obstructive pulmonary disease (Grailer et al., 2014; Hosseinian et al., 2015; Lee et al., 2016; Zhang et al., 2023). The gene discussed is NLRP3; the disease is pulmonary fibrosis.