These findings were confirmed and specified in multivariate Cox regression analysis, where the groups containing patients with high IL‐6 and sarcopenia or patients with high GDF‐15 and sarcopenia both were independently at risk for shorter OS and CSS (OS sarcopenia and high IL‐6: HR 3.99, 95%CI 1.81–8.81, p < 0.01; CSS sarcopenia and high IL‐6: HR 4.78, 95%CI 1.79–12.77, p < 0.01; OS sarcopenia and high GDF‐15: HR 2.97, 95%CI 1.15–7.70, p = 0.03; CSS sarcopenia and high GDF‐15: HR 3.43, 95%CI 1.02–11.56, p = 0.047; Tables S5 and S6). The gene discussed is GDF15; the disease is sarcopenia.