In the case of PSEN2 gene variants, the most common ones detected in all our stroke patients through WES are PSEN2 rs11405 (c.69T > C), PSEN2 rs6759 (c.129C > T), and PSEN2 rs1046240 (c.129C > T) (Table 8). The gene discussed is PSEN2; the disease is Stroke.