SERPINE1 and Stroke: Similarly, a significant association was observed in the dominant inheritance model between the PAI-1-(5G + 4G/5G) and PAI-1-4G genotypes, indicating an increased stroke risk, with an OR of 1.90 (95% CI = 1.0071 to 3.600), RR of 1.39 (0.9754 to 1.994), and a p-value of less than 0.047.