NOTCH3 and stroke disorder: Likewise, the most common NOTCH3 gene variants, as revealed by whole exome sequencing in all our stroke patients, include NOTCH3 rs15174241 (c.4563A > G), NOTCH3 rs15181626 (c.2742A > G), and NOTCH3 rs15192033 (c.606A > G) (Table 8).