In the dominant inheritance model, a strong association was noted between the PAI-1-5G and PAI-1-(4G5G+4G) genotypes, reflecting enhanced stroke risk, with an OR of 2.27 (95% CI = 1.2552 to 4.127), RR of 1.43 (1.1224 to 1.841), and a p-value of less than 0.006. This evidence concerns the gene SERPINE1 and Stroke.