In the recessive inheritance model, our study reported a significant association between the ANRIL genotypes (AA + AG) and susceptibility to stroke, with an OR of 3.14 (95% CI = 1.694 to 5.833), RR of 1.62 (95% CI = 1.1672 to 2.272), and a p-value less than 0.0003. This evidence concerns the gene CDKN2B-AS1 and stroke disorder.