For RNF213 gene variants, the predominant ones identified in all our stroke patients through whole exome sequencing are RNF213 rs8082521 (c.3544C > A), RNF213 rs8074015 (c.4139A > G), and RNF213 rs4890009 (c.4797G > A). The gene discussed is RNF213; the disease is stroke disorder.