SERPINE1 and Stroke: A significant association was also found in the codominant model between the PAI-1-5G and PAI-1-4G genotypes, indicating increased stroke risk, with an OR of 2.00 (95% CI = 1.0505 to 3.829), RR of 1.62 (1.1228 to 2.358), and a p-value of less than 0.034.