SERPINE1 and cardiovascular disorder: Mutations mostly 4G/5G guanine nucleotides insertion/deletion polymorphism at position 675 of the Plasminogen activator inhibitor-1 (PAI-1) promoter [27,28], leads in its increased levels and result in decreased plasma fibrinolytic activity, a phenomenon observed in metabolic syndrome [29], cardiovascular disease and myocardial ischemia [30,31].