Based on the aforementioned association, we identified LILRA5, HNRNPL, and AGBL3 as common hub genes for Osteoporosis and stroke, which have been externally validated in GEO transcriptomic data (AUC > 0.8) and have the potential to be developed as low-cost qPCR or liquid biopsy biomarkers. The gene discussed is LILRA5; the disease is osteoporosis.