The degradation of OPG by AGBL3 accelerates osteoclastic resorption, while the hydrolysis of OPN promotes vascular calcification—two processes that are highly consistent with the comorbid characteristics of Osteoporosis and stroke (e.g., vascular calcification in Osteoporosis patients and bone loss in stroke patients) [6,25]. This evidence concerns the gene AGBL3 and Stroke.