To elucidate the potential mechanisms of LILRA5, HNRNPL and AGBL3 in Osteoporosis and stroke, a protein-protein interaction (PPI) network was constructed using GeneMANIA, including 3 core genes and their 20 direct interacting partners, forming a functional network with 23 nodes (Fig 5A). The gene discussed is AGBL3; the disease is osteoporosis.