CASP8AP2 and acute lymphoblastic leukemia: Many studies have reported the importance of the initial gene level of CASP8AP2, an apoptosis-related gene, for the optimal response to chemotherapy and maintaining continuous complete remission in pediatric ALL, as concluded by Flotho et al., Jiao et al., Jin et al., Juarez-Velazquez et al., Liu et al., and Remke et al. [21–27].