One case involved a 76-year-old man with genetically confirmed KS who developed an oncocytic gonadotrophic macroadenoma.(8) Another case report described a man with long-standing hypogonadism who developed a gonadotropinoma immunoreactive for both FSH and LH.(8) Additionally, a 57-year-old patient with KS was reported to have a pituitary gonadotropinoma, further highlighting the rare but significant association between KS and pituitary adenomas.(9). The gene discussed is PLOD1; the disease is hypogonadism.