NPPB and hydrops fetalis: In the CARE-HF trial of CRT, for example, CRT was associated with significant improvements in LVEF and NT-proBNP, which paralleled reductions in mortality and HF hospitalizations.26 Similar associations were seen in the BUDAPEST-CRT Upgrade Trial, where reverse remodelling (including a change in LVEF) occurred alongside substantial reductions in the composite of mortality and HF hospitalization.27,28