PFKFB3 and colitis: Cell-specific temporal analysis revealed macrophage-driven PFKFB3 elevation at earlier DSS treatment phases, differing from severe-stage stromal elevation reported by Zhou: Zhou et al. reported that stromal PFKFB3 expression became significantly enhanced only during severe colitis, whereas our data show PFKFB3 upregulation occurs primarily during days 3–5 of DSS treatment.