PFKFB3 and colitis: Given the pronounced upregulation of PFKFB3 expression in myeloid cells, particularly macrophages and the central role of innate immune cells in colitis, we generated myeloid-specific PFKFB3 knockout mice by crossing PFKFB3fl/fl mice with Lyz2-Cre mice (PFKFB3fl/flLyz2-Cre) (Fig. S4).