Meanwhile, in addition to oxidative stress, numerous molecular events, such as the miR‐450b‐5p/CRYAB axis [70], the FBXW5/ASK1/TRAF6 axis [71], and the miR‐22/FAM49B‐mediated TRAF6/IKK pathway [72], are involved in inflammatory response [70, 71, 72, 73], cell apoptosis [74, 75, 76], and mitochondrial dysfunction [77] pathways, playing critical roles in hepatic/renal/myocardial ischemia–reperfusion injury. Here, FBXW5 is linked to myocardial ischemia.