NPC1 and neoplasm: Given the role of inadequate nuclear organization and trafficking in malignant states [58], we further studied the components involved in proteasome shuttling through the NPC, finding that p62, together with its homolog NBR1, is required for proteasome translocation (Figure 2), a movement that is also dependent on the NPC member protein NUP93, which was recently shown to enhance tumor aggressiveness [54,59].