Furthermore, high expression of androgen signalling-related genes PAGE4 and SRD5A1 in scRNA-seq cluster F3 implies tissue-specific features of prostate iCAF, which as reported recently by us, may further underlie their positive prognostic association as stromal AR suppresses PCa progression (Brunner et al., 2025; Liu et al., 2022). This evidence concerns the gene AR and posterior cortical atrophy.