MTOR and atherosclerosis: It has been demonstrated that mTOR signaling is essential for heart physiological processes regulation such as growth, aging, and lifespan, as well as for playing a pivotal role in pathological conditions such as atherosclerosis and ischemia–reperfusion injury (Park et al., 2016; Yuan et al., 2014; Li et al., 2019; Gurusamy et al., 2010; Liu et al., 2021).