Through PCA, it was revealed that cGAMP STING, nucleus and cytoplasmic FOXO1 and FOXO3a, nuclear STING, and ATG12/5 are one of the key determinants in the cGAS STING pathway, mediating the autophagy process in the reconstructed NSCLC model (Figure 2a). Here, CGAS is linked to non-small cell lung carcinoma.