The reconstructed mathematical model of cGAS–STING signaling promoting autophagy in NSCLC was generated with six compartments including cytoplasm, PM, ER, Golgi apparatus, and ERGIC with 72 species and 83 reactions and was simulated for 100 s with a Stiff Deterministic ODE15s solver (SimBiology toolbox). This evidence concerns the gene STING1 and non-small cell lung carcinoma.