Cox regression analysis, adjusting for PD-L1 expression (protein level), smoking status, gender, age, histology (adenocarcinoma vs. squamous), and co-mutations (KRAS, TP53, KEAP1, STK11), further confirmed redox status as the only significant predictor of reduced OS (HR 3.60 [1.54 -8.41], P = 0.00306) and PFS (HR 3.12 [1.09-8.94], P = 0.0337) in univariate analysis but not multivariate analysis (Supplementary Tables 8.1, 8.2). This evidence concerns the gene CD274 and adenocarcinoma.