Whole-exome sequencing revealed an elevated somatic copy number alteration burden and pathogenic variants in ARID1A, KMT2D, BCL7A, PTPN11, and NUP214, suggesting disruptions in chromatin remodeling, B-cell neoplasm pathogenesis, and oncogenic signaling driving the tumorigenesis. This evidence concerns the gene PTPN11 and B-cell neoplasm.