Ang-2, angiopoietin-2; AP, acute pancreatitis; BISAP, bedside index for severity in acute pancreatitis; CRP, C-reactive protein; CRP/ALB, C-reactive protein to albumin ratio; HGF, hepatocyte growth factor; HTGP, hypertriglyceridemic pancreatitis; MCTSI, modified computed tomography severity index; NLR, neutrophil-to-lymphocyte ratio; POF, persistent organ failure; RDW, red cell distribution width; RDW-to-ALB, red cell distribution width to albumin ratio; SAP, severe acute pancreatitis; SIRT1, silent information regulator 1; TNF-R1A, tumor necrosis factor receptor 1A. The gene discussed is ANGPT2; the disease is alkaline phosphatase measurement.