↑Tumor inhibition rate↑The CD8+/CD4+ ratio in tumor and spleen ↓FoxP3+ regulatory T cells in spleen↑IFN-γ, GZMB and TNF-α ↑Beneficial bacteria: Bifidobacterium, Faecalibaculum and Lactobacillus↑Short-chain fatty acids. The gene discussed is TNF; the disease is neoplasm.