NFKB1 and osteosarcoma: miRNAs mediate inflammatory regulation, such as in Tyrophagus putrescentiae where miRNAs target allergen mRNAs to modulate their expression (Wang et al., 2019), and in osteosarcoma where NF-κB downregulates miR-506 to promote cell proliferation via JAG1 (Hu et al., 2017).