Additionally, in bladder cancer, CircNR3C1 can bind to BRD4 and interfere with the formation of the oncogenic complex between C-myc, thereby inhibiting tumor progression (Ding et al., 2021); studies have also shown that the ectopic expression of C-myc can partially reverse the tumor suppressive effect of this circRNA in vivo (Xie et al., 2020). Here, BRD4 is linked to neoplasm.