However, dysregulation of MTs can have a significant impact on whole body physiology; e.g. defective regulation of glucose transporter-4 (GLUT4) is a key driver of insulin resistance and type-2 diabetes (Klip et al. 2019), and a failure in neuronal MTs has been shown to impair cognitive function and/or be linked to neurodegenerative disorders (Kiral et al. 2018). This evidence concerns the gene SLC2A4 and type 2 diabetes mellitus.