To address this, our study investigates the potential of specific genes (MB, TP53, CENPA, BUB1B, MAD2L and ZWINT) and microRNAs (hsa-mir-607, hsa-mir-556-5p, hsa-mir-1225-3p, hsa-mir-361-3p) as prognostic markers and therapeutic targets for oral cancer. The gene discussed is CENPA; the disease is lip and oral cavity carcinoma.