In conclusion, it appears that MB, TP53, CENPA, BUB1B, MAD2L, ZWINT, hsa-mir-607, hsa-mir-361-3p, hsa-mir-556-5p, and hsa-mir-1225-3p plays a crucial role as mediators in cancer progression, influencing OSCC development through complex mechanisms. This evidence concerns the gene BUB1B and cancer.