Importantly, the number of metastatic lung nodules was reduced by adding Akt inhibitor to RT + αPD-L1/αCTLA-4 (Figures 4C and 4D), suggesting that Akt inhibitor contributed to enhanced local and systemic anti-tumor responses even when it was added to RT + αPD-L1/αCTLA-4. Here, AKT1 is linked to neoplasm.