Acute phase reactants such as ESR, ferritin, haptoglobin, α1-acid glycoprotein, and serum amyloid P have been associated with various cardiovascular risk factors such as coronary artery disease, coronary plaque volume, the development of heart failure, and increased risk for both MI and stroke, angina and atherosclerosis [23–27]. This evidence concerns the gene ESR1 and coronary artery disorder.