LRRK2 and Parkinson disease: To assess basal oxidative stress levels in the SNc and striatum of an LRRK2 BAC-hR1441G PD model, we crossed these mice with TH-mito-roGFP reporter mice, which express a mitochondria-targeted, redox-sensitive green fluorescent protein under the control of the TH promoter, generating LRRK2 BAC-hR1441G/TH-mito-roGFP mice.