TF and neuroblastoma: For cell-type-specific analyses, qQTL-only variants in single-nucleus eQTLs were most strongly enriched in regulatory annotations from other cell types rather than the matched cell type (for astrocytes using TF ChIP-seq annotations: 1.73-fold, p=1.41×10−31 in neuroblastoma versus 1.08-fold, p=8.85×10−13 in astrocytes; Figure 2d), suggesting that genetic effects in one cell type may depend on the regulatory state or signaling from other cell types, potentially reflecting cell-cell communication mechanisms or trans-cellular regulatory influences in the brain.