The chromosomal region harboring CHRNE (cholinergic receptor nicotinic epsilon subunit)32, SCIMP (SLP adaptor and CSK interacting membrane protein)33, and RABEP1 (rabaptin, RAB GTPase binding effector protein 1)34 contains multiple AD-associated variants in moderate linkage disequilibrium, but the causal gene targets remain unresolved. This evidence concerns the gene SCIMP and Alzheimer disease.