Mgl2 KO tumors displayed significant enrichment of immune and inflammatory pathways, including TNF-α/NF-κB, IL-6/JAK-STAT3, interferon-α/γ, and IL-17 signaling—pathways broadly associated with myeloid activation, cytokine production, and tumor immunosurveillance 53,54. This evidence concerns the gene IL6 and neoplasm.