TAMs were subdivided into transcriptionally defined subsets reflecting distinct functional programs: C1QC+ macrophages, associated with immunosuppression 47–49; NLRP3+ macrophages, associated with poor prognosis and tumor growth 50,51; and INHBA+ macrophages, linked to angiogenesis, matrix remodeling, and tumor progression 52 (Fig. 3G; Suppl. Here, C1QC is linked to neoplasm.