Cross‐validated SNPs rs16969968/rs12914385, cis‐regulatory hubs for COPD–lung cancer pathogenesis, colocalized with ρ‐HESS‐identified regions, mechanistically linking dysregulation of PSMA4, IREB2, CHRNA3, and CHRNA5 to disease etiology (Data S26). The gene discussed is PSMA4; the disease is lung cancer.