GPBAR1 and infection: ,14 To verify the role of Tgr5 in macrophages during sepsis, we generated myeloid cell-specific Tgr5 knockout (Tgr5LysMCre) mice and infected them with L.m. 40% of Tgr5LysMCre animals reached the experimental endpoint criteria within eight days, whereas all of the Tgr5fl/fl littermates survived the infection (Figure 2F).