Among these alterations, an investigation into the Neogenin-1 transcript, a gene that is linked to cancer,10,11,12 revealed that the formation of the distal 3′-UTR rG4 seemed to exert a stronger influence on both the selection of the PAS and on the production of long isoforms than did the formation of the proximal 3′-UTR rG4. Here, NEO1 is linked to cancer.