BECN1 and familial pancreatic carcinoma: As shown in Fig. 6L, CaCO3@CM-OA treatment also increased the expression of Beclin 1 and LC3B/LC3A, indicating the activation of autophagy signaling pathway Detection of N-cadherin and Vimentin showed that CaCO3@CM-OA also inhibited the epithelial-mesenchymal transition (EMT) process of pancreatic cancer in vivo (Fig. 6M).