Compared with previous meta-analyses that identified effective combinations of non-pharmacological and pharmacological interventions, such as cognitive stimulation combined with rehabilitation (48) and cognitive stimulation combined with cholinesterase inhibitors (5), for alleviating depressive symptoms in individuals with dementia (predominantly without major depressive disorder), our findings highlight GAME and mindfulness as the most promising single-modality interventions. The gene discussed is BCHE; the disease is major depressive disorder.