Additionally, the suggested mechanism of a “Th2 shift” leading to HLH lacks direct support in the search results, as HLH is mainly characterized by a cytokine storm that is dominated by Th1-type cytokines like IFN-γ, with IL-10 being a significant counter-regulatory Th2 cytokine[15]. The gene discussed is IFNG; the disease is hemophagocytic syndrome.