Fibroblast-specific deletion of Rock2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction; ROCK2Postn−/− mice had reduced left ventricular (LV) wall thickness and fibrosis, along with improved isovolumetric relaxation in response to angiotensin II (Ang II) compared to the control. The gene discussed is AGT; the disease is cardiac hypertrophy.