According to age distribution, GBM patients exhibited the oldest median age at diagnosis (52 years), followed by patients with IDH1/2-wild-type glioma (39 years), patients with oligodendroglioma (44 years), and patients with IDH1/2-mutant astrocytoma (38 years; Fig. 2A). The gene discussed is IDH1; the disease is astrocytoma (excluding glioblastoma).